Investigating giardiasis and long term complications

Bergen Giardia Research Group

Kindergarden outbreak investigation

In March 2010 the finding of several cases of giardiasis in a kindergarten in Bergen sparked an outbreak investigation. The investigation aims at characterising symptoms, risk factors, and Giardia genotypes. Possible recent infections among children will also examined by analysing Giardia specific immune responses in saliva.

 

Giardia induced fatigue and functional gastrointestinal disorders - characterization and treatment trial

Recruiting patients from April 2009 until Mai 2010, this study aims to thoroughly assess immune responses, functional aberrations in the brain and other possible biomarkers for the abdominal symptoms and chronic fatigue syndrome observed after Giardia infection. Persons with persisting fatigue complaints were offered one of two treatment options - psycoeducative training or behavioural cognitive training. Analyses are ongoing.

 

Duodenal immune responses in chronic giardiasis and mechanisms for development of post-infectious functional gastrointestinal disorders

In many of the referred patients with persistent abdominal symptoms an unexpectedly high frequency of intestinal inflammation was found. Studies of duodenal biopsies from these patients and healthy controls are being performed to evaluate the involvement of T and B-cells in this inflammatory process.

 

Prevalence of functional gastrointestinal disorders and chronic fatigue 3, 6 and 10 years after the Giardia epidemic

Post-infectious irritable bowel syndrome and post-infectious chronic fatigue syndrome have been reported following infections with several agents. These studies investigate the prevalence of functional gastrointestinal disorders according to the Rome III criteria, and chronic fatigue according to a Fatigue Questionnaire in 1250 patients with confirmed diagnosis of giardiasis and an age and sex matched control-group. Additionally, we have investigated whether atopic disease, overactive bladder syndrome, subjective food intolerance and sleep is associated with the post-infectious symptoms observed.

 

Previous studies - publication list

Research Projects

Webansvarlig: Kurt Hanevik