Investigating giardiasis and long term complications

Bergen Giardia Research Group

 

Duodenal immune responses in chronic giardiasis and mechanisms for development of post-infectious functional gastrointestinal disorders

In many of the referred patients with persistent abdominal symptoms an unexpectedly high frequency of intestinal inflammation was found. Studies of duodenal biopsies from these patients and healthy controls are being performed to evaluate the involvement of T and B-cells in this inflammatory process.

 

Prevalence of functional gastrointestinal disorders and chronic fatigue 3, 6 and 10 years after the Giardia epidemic

Post-infectious irritable bowel syndrome and post-infectious chronic fatigue syndrome have been reported following infections with several agents. These studies investigate the prevalence of functional gastrointestinal disorders according to the Rome III criteria, and chronic fatigue according to a Fatigue Questionnaire in 1250 patients with confirmed diagnosis of giardiasis and an age and sex matched control-group. Additionally, we have investigated whether atopic disease, overactive bladder syndrome, subjective food intolerance and sleep is associated with the post-infectious symptoms observed.

 

Metronidazole resistance in Giardia

Clinical resistance against the commonly used drug metronidazole is increasing in Giardia, especially in travellers form the Indian subcontinent. Through collection of clinical isolates and genetic characterization of clinically susceptible and resistant strains we are looking for markers and mechanisms of metronidazole resistance in Giardia. We also perform functional characterization of proteins involved in the metronidazole metabolism and oxidative/nitrosative stress regulation pathways.

 

Giardia vaccine targets

We have been examining the genetic variation in Giardia vaccine targets alfa-1-giardin and Cyst wall protein 2. Further work includes characterising human immune responses to these proteins.

 

 

 

 

Previous studies - publication list

Ongoing Research Projects

Webansvarlig: Kurt Hanevik